Latino Studies at New York University

David Wootton

Image-based modeling of the upper airway in Obstructive Sleep Apnea Syndrome

September 27, 2011

Obstructive Sleep Apnea Syndrome (OSAS) is defined by repeated episodes of pharyngeal airway obstruction during sleep, and has been the subject of increased study and publicity due to a variety of detrimental effects such as increased accident risk, hypertension, accelerated heart disease, and insulin resistance.  OSAS is associated with both abnormal anatomy and abnormal function, and currently there is no model that integrates anatomical and functional factors to predict pharyngeal stability.  Dr. Wootton will talk about his research team's approaches to model the pharyngeal flow field using CFD based on magnetic resonance images, to quantify the effect of anatomical narrowing on airway pressures in children with OSAS, and more recent models to estimate local airway compliance, based on dynamic MR imaging and CFD.  The itnerpretation of airway compliance using theoretical models will be discussed.