Icahn Institute for Genomics and Multiscale Biology and Icahn School of Medicine at Mount Sinai
December 3, 2013
Connecting High-throughput Data to Build Better Models of the Immune System in Health and Disease
The immune system is a complex network of interacting cells and molecules that orchestrate essential defense mechanisms to protect the host against pathogens and disease. Despite decades of productive research on the immune system and numerous immuno-modulatory therapies, no robust set of metrics for human immune health currently exists. Many technological advances in high-throughput assays have made it possible to measure many thousands of immunological parameters from individuals. In this talk, I will discuss our efforts to integrate these measurements to define metrics for human immune monitoring to diagnose immunological health and to develop better models of drug immune-cell interactions that can be used to guide treatment for immune-mediated diseases.