Department of Mathematics
University of Iowa
October 8, 2013
The unfolded protein response in mammalian cells under stress: a modeling approach
The unfolded protein response (UPR) is a cellular mechanism whose primary functions are to sense perturbations in the protein-folding capacity of the endoplasmic reticulum and to take corrective steps to restore homeostasis. Although the UPR is conserved across all eukaryotic cells, it is considerably more complex in mammalian cells due to the presence of three interconnected pathways triggered by separate sensor proteins, a translation attenuation mechanism, and a negative feedback loop. This talk will introduce a quantitative mathematical model for the dynamics of the UPR as a network of interacting proteins and mRNAs. The model is validated using experimental data collected on mouse embryonic fibroblasts.