Latino Studies at New York University

Larry Sirovich

Mount Sinai School of Medicine/Rockefeller

March 8, 2011

Behavior of Spiking Neurons:  Analyzes & Speculations

A model of a neuron's interspike interval probability density is derived through analysis of the first passage problem. The fit of our expression to retinal ganglion cell laboratory data extracts three physiologically relevant parameters, with which our model yields
input-output features that conform with laboratory results. Preliminary analysis suggests that under common circumstances local circuitry readjusts these parameters with changes in firing rate, and so endeavors to faithfully replicate an input signal. Further results suggest that the "principle of sloppy workmanship" also plays a role in evolution's choice of these parameters.