Latino Studies at New York University

Christian Schmeiser

University of Vienna

Cell motility by cytoskeleton dynamics

June 4, 2015

The lamellipodium is a flat cell protrusion functioning as a motility organelle for cells on flat substrates. It is a very dynamic structure mainly consisting of a network of filaments of polymerized actin. The Filament Based Lamellipodium Model is a two dimensional, two-phase, anisotropic continuum model for the dynamics of this network, which has been developed over the past 8 years. It has been derived from a microscopic description based on the dynamics and interaction of individual filaments. Some aspects of the derivation of the model, of its analysis, and of its numerical solution will be presented, together with some recent simulation results.  (joint work with A. Manhart, D. Oelz, N. Sfakianakis, J.V. Small)