Professor, Institute for Applied Mathematics
National University of Mexico
September 23, 2014
Morphogenetic models: from genetic networks to patterns.
In developmental biology the problem of determining the differentiation fate of a cell depending on genetic or positional information and context in general is to a large extent open. Understanding how this process in turn leads to specific functional structures is even more challenging. We consider in this talk how experimental results can be used to construct a dynamical system that accounts for some of the observed features during development. In particular, we provide a methodological framework for constructing an epigenetic landscape that can be used to emulate the space-time dynamics of the underlying biological system. As a model we take cell fate determination during the preflowering process in Arabidopsis thaliana and the early stages of embryo development in mice.