Courant Institute of Mathematical Sciences
New York University
Cell Movement - Zooming In
This talk is devoted to actin-dependent cell movement, in particular it is concerned with cells that crawl with the aid of a lamellipodium. This sheet-like structure consists of a network of actin filaments together with several accessory proteins. The basis of the work presented is the Filament Based Lamellipodium Model (FBLM), a 2-dimensional, 2-phase PDE model. We made several modeling additions, for example detailed models describing the filament number and length regulation or adding a description of myosin. I will demonstrate that with these extensions the model is able to simulate the chemotatic behavior of cells, the movement on variable adhesion patterns, or the bistability of lamellipodial fragments. The presented results use numerical as well as analytical techniques.