### Ben Fogelson

Courant Institute of Mathematical Sciences

New York University

December 2, 2014

Force scaling behavior of actomyosin stress fibers

Actin stress fibers are important mechanical elements of many cells, but for typical cells the geometry and interconnectedness of the cytoskeleton makes it hard to get a quantitative understanding of how an individual stress fiber behaves and, in particular, how much force it generates. Growing cells on a micropatterned substrate constrains their shape and can simplify the stress fiber geometry. By using data from cells grown on such a substrate, we construct a simple 1-D model of actomyosin force production to explain a puzzling peak in force production at intermediate stress fiber lengths.